About NLME module
Background
Population PK/PD modeling and its variations are arguably one of the most used types of model-based analyses in MIDD. The development of such models follows a rigid workflow that includes such steps as structural model selection, statistical model selection, covariate search, and forward simulations. Mechanistic, or QSP models, utilize similar functionality, however, with a lot of nuances. For example, covariate search is not typically performed in QSP as relevant covariates ought to be included as a part of the structural model rather than a parameter. At the same time, the QSP approach demands additional set of tools, such as sensitivity analyses, likelihood profiling, or parameter estimation via virtual populations simulation.
Objectives
- Implementation and modification of structural, statistical and covariate models.
- Estimation of unknown parameters within the model using different algorithms and approaches.
- Extensive model diagnostics and evaluation.
- Automatic model development and assessment.
- Model-based simulations.