This guide is relevant for Simurg Environment version 0.12.9 and above.

About Simurg

Simurg environment represents a unique easily-deployable and operatable software platform that seamlessly merges novel model-based techniques and algorithms with existing well-established software and workflows in a convenient GUI in order to perform the broadest spectrum of model-based analyses relevant for quantitative pharmacology.

Objectives

  1. Data handling and processing.
  2. Exploratory data analysis and quality check.
  3. Solving the direct problem for mathematical models based on various types of differential equations.
  4. Parameter estimation procedures for non-linear and linear systems with or without random effects.
  5. Development of regression models for various types of data (binary, categorical, etc.).
  6. Meta-analysis and meta-regression.
  7. Model development in Bayesian paradigm.
  8. Generation of reports based on the results of the analyses.

Simurg environment modules

  1. Data management module - semi-automatic data processing, visualization and quality check.
  2. NLME module - mathematical modeling of dynamical data using hierarchical modeling with frequentist and Bayesian approach suitable for both empirical and mechanistic models.
  3. MultiReg module - expands the range of data types and associated mathematical methods a modeler can use within Simurg environment.
  4. Reporting module - compile and update modeling reports in various formats.