Initial estimates

Good initial estimates of model parameters values speed up the subsequent estimation. The Simurg Platform provides the ability to visually evaluate the model predictions with the selected initial values for the fixed effects. To use it select “Initial estimates” tab.

Be aware of previous initialization of Data and Model on the corresponding tabs.

Click button "Check initial estimates" to explore the initial values from the model file.

As Simurg/RxODE syntax provides the ability to set values for the parameters directly in the model file, "Initial estimates" tab will return values form the corresponding model file. For mlxtran syntax the initial values for parameters will be set to "1" by default.

You can modify the values of the parameters for the fixed effects on the right panel. To evaluate how the proposed values corresponds to the data click button "Show plots" - plots of the model's predictions and measurements for each ID in the dataset will be displayed. In case of several outputs in the project you can selectize the output of interest for visualization. In addition, you can change the axis to log-scale and adjust the limits of each axes.

If you want to reset the parameters values to the initial ones, click button "Check initial estimates".

When you are confident with the initial values, you could proceed to the "Task" tab for statistical components initialization. The last values ​​you entered will be set as the initial values ​​for subsequent evaluation.